Neves, Joana2021-03-262021-03-262020Science. 2020 Mar 13;367(6483):1205-12060036-8075http://hdl.handle.net/10451/47103Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science.A central promise of regenerative medicine is the ability to repair aged or diseased organs using stem cells (SCs). This approach will likely become an effective strategy for organ rejuvenation, holding the potential to increase human health by delaying age-related diseases. The successful translation of this scientific knowledge into clinical practice will require a better understanding of the basic mechanisms of aging, along with an integrated view of the process of tissue repair. The advent of SC therapies, now progressing into clinical trials, has made clear the many challenges limiting the application of SCs to treat disease. Our duty, as scientists, is to anticipate such limitations and propose solutions to effectively deliver on the promise of regenerative medicine.engjournal article10.1126/science.aba61141095-9203