MAPKs are key players in mediating cytokine release and cell death induced by unconjugated bilirubin in cultured rat cortical astrocytes

Fernandes, AdelaideFalcao, Ana S.Silva, Rui F. M.Brito, Maria A.Brites, Dora2015-12-302015-12-302007EUROPEAN JOURNAL OF NEUROSCIENCE. - Vol. 25, n. 4 (FEB 2007), p. 1058-10680953-816Xhttp://hdl.handle.net/10451/21564When activated by unconjugated bilirubin (UCB), astrocytes are important sources of inflammatory mediators such as TNF-alpha, IL-1 beta and IL-6, which may contribute for the neurotoxicity observed during severe neonatal hyperbilirubinemia. In the presentapplication/pdfengNeurosciencesMAPKs are key players in mediating cytokine release and cell death induced by unconjugated bilirubin in cultured rat cortical astrocytesjournal articlehttp://dx.doi.org/10.1111/j.1460-9568.2007.05340.x