Barros Pinto, Marco P.Cristino, José Melo2023-01-092023-01-092022Diagn Cytopathol. 2023 Feb;51(2):153-1558755-1039http://hdl.handle.net/10451/55710© © 2022 The Authors. Diagnostic Cytopathology published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.Cryptococcosis have a worldwide distribution and is responsible for wide range of clinical presentations (mainly pulmonary, central nervous system, skin and prostate infections, but bone, peritoneum and urinary system infections are sometimes described). Infection start primarily by inhalation of environmental basidiospores or poorly encapsulated yeast cells (with less than 5 μm), that can disseminate, after a latent period within lung lymph nodes. There are two principal species of Cryptococcus spp related with this disease: Cryptococcus neoformans and Cryptococcus gattii. Cryptococcus albidus and Crytpococcus laurentii are rarely associated with cryptococcosis in humans.engjournal article10.1002/dc.250901097-0339