Muñoz-Ruiz, MiguelSumaria, NitalPennington, Daniel J.Silva-Santos, Bruno2022-06-082022-06-082017Trends Immunol. 2017 May;38(5):336-3441471-4906http://hdl.handle.net/10451/53345© 2017 Elsevier Ltd. All rights reserved.γd T cells have emerged as major sources of the proinflammatory cytokines interleukin-17 (IL-17) and interferon-γ (IFNγ) in multiple models of infection, cancer and autoimmune disease. However, unlike their αβ T cell counterparts that require peripheral activation for effector cell differentiation, γδ T cells instead can be 'developmentally programmed' in the thymus to generate discrete γδ T cell effector subsets with distinctive molecular signatures. Nonetheless, recent studies have presented conflicting viewpoints on the signals involved in thymic γδ T cell development and differentiation, namely on the role of both T cell receptor (TCR)-dependent and TCR-independent factors. Here we review the current data and the ongoing controversies.engIFN-γIL-17T-cell developmentTCRThymusγδ T cellsjournal article10.1016/j.it.2017.01.0071471-4981