Mensurado, SofiaSilva-Santos, Bruno2022-10-202022-10-202022Trends Cancer. 2022 Nov;8(11):881-8832405-8033http://hdl.handle.net/10451/54843© 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).In a study in Science, Reis et al. describe a temporal segregation of γδ T cell activities in colorectal cancer (CRC). Initially tumor surveillance is orchestrated by interferon-γ (IFN-γ)-producing and cytotoxic γδ T cell subsets, but once the tumor thrives, it becomes infiltrated by interleukin (IL)-17+ γδ T cell subsets that promote its growth.engjournal article10.1016/j.trecan.2022.08.0062405-8025