Sousa, Pedro A.Barra, SérgioCortez-Dias, NunoKhoueiry, ZiadPaulo, JoséAntónio, NatáliaFerreira, Afonso NunesPereira, MarianaLagrange, PhilippeDe Sousa, JoãoElvas, LuísGarcia, Fermin C.Gonçalves, Lino2023-07-212023-07-212023Int J Cardiol. 2023 Jul 15;383:33-390167-5273http://hdl.handle.net/10451/58714© 2023 Elsevier B.V. All rights reserved.Purpose: We aim to evaluate whether the use of a multielectrode mapping catheter could lead to higher efficacy of premature ventricular contraction (PVC) ablation. Methods: Prospective, multicenter nonrandomized study of consecutive patients referred for PVC ablation from January 2018 to June 2021. Patients were separated into two groups: activation map performed with the PentaRay catheter (Study group) or with the ablation catheter (Control group). PMF software was used in both groups. Procedural endpoints and 1-year freedom from ventricular arrhythmia were assessed. Results: During the enrollment period 136 patients (60% males, mean age of 55 ± 17 years, 60% left-sided origin) fulfilled the inclusion criteria - 68 patients in each group. Patients in the Study Group had a sevenfold higher number of acquired activation points (768 ± 728 vs. 110 ± 79, p < 0.01), a shorter mapping time (28 ± 19 min vs. 49 ± 32 min, p < 0.01) and a quicker procedure time (110 ± 33 min vs. 134 ± 50 min, p < 0.01), compared to patients in the Control Group. While there were no significant differences in the acute success (95.6% in the Study Group vs. 90.1% in Control group, p = 0.49), or adverse events (4% in the Study group vs. 7% in the Control group, p = 0.72), patients in the Study group had a higher freedom from ventricular arrhythmia at 1-year (89.7% vs. 70.6%, p = 0.01). The use of the PentaRay catheter was an independent predictor of success (HR = 6.20 [95% CI, 1.08-35.47], p = 0.003). Conclusions: The use of the PentaRay catheter may improve the outcome of PVC ablation while reducing procedure time.engCatheter ablationPattern matching filter softwarePentaRay catheterPremature ventricular contractionjournal article10.1016/j.ijcard.2023.04.0441874-1754