Bártolo, InêsCamacho, RicardoBarroso, HelenaBezerra, VictorTaveira, Nuno2025-08-142025-08-142009Bártolo I, Camacho R, Barroso H, Bezerra V, Taveira N. Rapid clinical progression to AIDS and death in a persistently seronegative HIV-1 infected heterosexual young man. AIDS 2009;23:2359–62. https://doi.org/10.1097/QAD.0b013e328332d5e1.http://hdl.handle.net/10400.5/102929Seronegative HIV-1 infection has important implications for diagnosis and prevention. We describe a case of HIV-1 infection without seroconversion and fast progression to AIDS and death. Genetic and phylogenetic analysis indicated that the patient was infected with a CRF14_BG-like strain selectively transmitted by his seropositive sexual partner. The results suggest a massive infection with a highly aggressive CRF14_BG-like strain and/or the presence of an unidentified immunological deficiency that has prevented the formation of HIV-1-specific antibodies.engjournal article2023-02-03cv-prod-110846910.1097/QAD.0b013e328332d5e12-s2.0-70449344717