Tsvetanov, Kamen A.Gazzina, StefanoJones, P. SimonSwieten, JohnBorroni, BarbaraSanchez‐Valle, RaquelMoreno, FerminLaforce, RobertGraff, CarolineSynofzik, MatthisGalimberti, DanielaMoore, Katrina MDuro, DianaFenoglio, ChiaraFerrari, CamillaFerreira, CarlosFerreira, Catarina B.Flanagan, TobyFox, NickFreedman, MorrisFumagalli, GiorgioPanman, JessicaGabilondo, AlazneGasparotti, RobertoGauthier, SergeGazzina, StefanoGiaccone, GiorgioGorostidi, AnaGreaves, CarolineGuerreiro, RitaHeller, CarolinHoegen, TobiasPapma, JanneIndakoetxea, BegoñaJelic, VesnaJiskoot, LizeKarnath, Hans‐OttoInstitutet, KarolinskaKeren, RonLangheinrich, TobiasLeitão, Maria JoãoLladó, AlbertLombardi, GemmaPiaceri, IreneLoosli, SandraMaruta, CarolinaMead, SimonMeeter, LiekeMiltenberger-Miltenyi, Gabrielvan Minkelen, RickMitchell, SaraNacmias, BenedettaNeason, MollieNicholas, JenniferPievani, MichelaOlives, JaumePadovani, AlessandroPijnenburg, YolandePolito, CristinaPremi, EnricoPrioni, SaraPrix, CatharinaRademakers, RosaMasellis, MarioRedaelli, VeronicaRittman, TimRogaeva, EkaterinaRosa‐Neto, PedroRossi, GiacominaRossor, MartinSantiago, BeatrizScarpini, ElioSchönecker, SonjaSemler, ElisaTartaglia, Maria CarmelaShafei, RachelleShoesmith, ChristenTábuas‐Pereira, MiguelTainta, MikelTaipa, RicardoTang‐Wai, DavidThomas, David LThompson, PaulThonberg, HakanTimberlake, CarolynFinger, ElizabethTiraboschi, PietroVandamme, PhilipVandenbulcke, MathieuVeldsman, MicheleVerdelho, AnaVillanua, JorgeWarren, JasonWilke, CarloWoollacott, IoneWlasich, ElisabethVandenberghe, RikZetterberg, HenrikZulaica, MirenDe Mendonça, AlexandreTagliavini, FabrizioSantana, IsabelDucharme, SimonButler, ChrisGerhard, AlexanderDanek, AdrianLevin, JohannesOtto, MarkusFrisoni, GiovanniGhidoni, RobertaSorbi, SandroRohrer, Jonathan D.Rowe, James B.Afonso, SóniaAlmeida, Maria RosarioAnderl‐Straub, SarahAndersson, ChristinAntonell, AnnaArchetti, SilvanaArighi, AndreaBalasa, MirceaBarandiaran, MyriamBargalló, NuriaBartha, RobartBender, BenjaminBenussi, LuisaBessi, ValentinaBinetti, GiulianoBlack, SandraBocchetta, MartinaBorrego‐Ecija, SergiBras, JoseBruffaerts, RoseCaroppo, PaolaCash, DavidCastelo-Branco, MiguelConvery, RhianCope, ThomasCosseddu, Maurade Arriba, MaríaDi Fede, GiuseppeDíaz, Zigor2021-04-062021-04-062020Alzheimers Dement. 2021 Mar;17(3):500-5141552-5260http://hdl.handle.net/10451/47260© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.Introduction: The presymptomatic phase of neurodegenerative disease can last many years, with sustained cognitive function despite progressive atrophy. We investigate this phenomenon in familial frontotemporal dementia (FTD). Methods: We studied 121 presymptomatic FTD mutation carriers and 134 family members without mutations, using multivariate data-driven approach to link cognitive performance with both structural and functional magnetic resonance imaging. Atrophy and brain network connectivity were compared between groups, in relation to the time from expected symptom onset. Results: There were group differences in brain structure and function, in the absence of differences in cognitive performance. Specifically, we identified behaviorally relevant structural and functional network differences. Structure-function relationships were similar in both groups, but coupling between functional connectivity and cognition was stronger for carriers than for non-carriers, and increased with proximity to the expected onset of disease. Discussion: Our findings suggest that the maintenance of functional network connectivity enables carriers to maintain cognitive performance.engFrontotemporal dementia (FTD)Functional magnetic resonance imaging (fMRI)Network connectivityPresymptomaticjournal article10.1002/alz.122091552-5279