5,10-Methylenetetrahydrofolate reductase 677C - T and 1298A - C mutations are genetic determinants of elevated homocysteine

Castro, RRivera, IRavasco, PJakobs, CBlom, HJCamilo, MEde Almeida, IT2015-12-302015-12-302003QJM-AN INTERNATIONAL JOURNAL OF MEDICINE. - Vol. 96, n. 4 (APR 2003), p. 297-3031460-2725http://hdl.handle.net/10451/21241Background: Methylenetetrahydrofolate reductase (MTHFR) is one of the main regulatory enzymes of homocysteine metabolism. Elevated plasma total homocysteine (tHcy) is a major risk for cardiovascular disease. A common 677C--T mutation in the MTHFR gene reapplication/pdfengMedicine, General & Internal5,10-Methylenetetrahydrofolate reductase 677C - T and 1298A - C mutations are genetic determinants of elevated homocysteinejournal articlehttp://dx.doi.org/10.1093/qjmed/hcg039