Cardoso, Ana RitaGonçalves, CristinaPascoalinho, DulceGil, CatarinaFerreira, António FernandesBártolo, InêsTaveira, Nuno2025-08-142025-08-142004Cardoso AR, Gonçalves C, Pascoalinho D, Gil C, Ferreira AF, Bártolo I, Taveira N. Seronegative infection and AIDS caused by an A2 subsubtype HIV-1: AIDS 2004;18:1071–4. https://doi.org/10.1097/00002030-200404300-00018.http://hdl.handle.net/10400.5/102927This work was supported by grant CRIA-CR3751 from Comissão Nacional de Luta Contra a SIDA, Portugal.The study of true seronegative HIV-1 infections may have important implications for the diagnosis and prevention of HIV-1 infection. The case of an AIDS patient with persistently negative HIV serology is described. Genetic and phylogenetic analysis indicated that she was infected with an A2 subsubtype HIV-1 transmitted by her seropositive and asymptomatic sexual partner. The clinical and serological discordant results suggest the presence of an immunological deficiency that prevents the formation of HIV-1-specific antibodies.engjournal article2023-02-03cv-prod-110846610.1097/00002030-200404300-000182-s2.0-2342567887