Carvalho, MamedeSwash, Michael2012-06-082012-06-082011J Neurol Neurosurg Psychiatry 2011;82:459-4610022-3050http://hdl.handle.net/10451/6491http://jnnp.bmj.com/content/82/4/459.full.pdf+htmldoi:10.1136/jnnp.2009.194019Copyright © 2012 by the BMJ Publishing Group Ltd. All rights reserved.Cramp-fasciculation syndrome (cramp-FS) is an ill-defined condition with uncertain clinical limits. The authors studied a 55-year-old man with progressively more severe, widespread fasciculations and cramps during a 6-year-period. Mild progressive lower motor neuron loss, shown by motor unit number and multi-motor unit potential (MUP) analysis, developed during the 4 years after onset, which stabilised during a further 2-year follow-up. Cramp-FS is generally a benign syndrome, probably with several causations. Our patient developed a limited form of anterior horn cell degeneration perhaps representing a syndrome transitional with amyotrophic lateral sclerosis. Cramp-FS merits more detailed study.engAmyotrophic lateral sclerosisCramp-fasciculation syndromeFasciculationsMyokymiaEMGMotor neuron diseasejournal article