Carreiras, Maria do CarmoEleutério, AnaDias, CatarinaBrito, Maria AlexandraBrites, DoraMarco-Contelles, JoséGómez-Sánchez, Elena2011-08-222011-08-222007Heterocycles, Vol. 71, No. 10, 2007, pp. 2249 - 22621881-0942http://dx.doi.org/10.3987/COM-07-11110http://hdl.handle.net/10451/3933The synthesis of 2-substituted 5-amino-4-cyano-1,3-oxazoles (1-4, 6-11) and the Friedländer-type reaction of compounds 1, 3, 4 is described. Compounds 13-17 are tacrine (18) analogues provided by the Friedländer reaction. The anti-cholinesterase activity of compounds 13, 14, 16 and 17 has been investigated.engjournal article