The bile acid tauroursodeoxycholic acid modulates phosphorylation and translocation of bad via phosphatidylinositol 3-kinase in glutamate-induced apoptosis of rat cortical neurons

Castro, RESola, SRamalho, RMSteer, CJRodrigues, CMP2015-12-302015-12-302004JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. - Vol. 311, n. 2 (NOV 2004), p. 845-8520022-3565http://hdl.handle.net/10451/21073Neurotoxicity associated with increased glutamate release results in cell death through both necrotic and apoptotic processes. In addition, tauroursodeoxycholic acid ( TUDCA), an endogenous bile acid, is a strong modulator of apoptosis in several cell typapplication/pdfengPharmacology & PharmacyThe bile acid tauroursodeoxycholic acid modulates phosphorylation and translocation of bad via phosphatidylinositol 3-kinase in glutamate-induced apoptosis of rat cortical neuronsjournal articlehttp://dx.doi.org/10.1124/jpet.104.070532