Falcão De Campos, CatarinaConceição, isabelCastro, IsabelCastro, José2021-11-292021-11-292019Amyloid. 2019;26(sup1):35-361350-6129http://hdl.handle.net/10451/50207© 2019 Informa UK Limited, trading as Taylor & Francis GroupHereditary amyloidosis related to transthyretin (hATTR) is a fatal progressive, autosomal dominant disease caused by mutations in the TTR gene. The most common TTR mutation worldwide is the V30M with a neuropathic phenotype, originating early impairment of small fibres responsible for the autonomic and sensory abnormalities frequently found as the first manifestation of disease. Diagnostic tools to assess autonomic function are essential in the diagnosis of small fibre neuropathy (SFNP) in early stages of disease, allowing an early treatment management.engjournal article10.1080/13506129.2019.15825031744-2818