Rodrigues, CMPSola, SBrito, MABrites, DMoura, JJG2015-12-302015-12-302002JOURNAL OF HEPATOLOGY. - Vol. 36, n. 3 (MAR 2002), p. 335-3410168-8278http://hdl.handle.net/10451/21053Background/Aims: Unconjugated bilirubin (UCB) impairs crucial aspects of cell function and induces apoptosis in primary cultured neurones. While mechanisms of cytotoxicity begin to unfold, mitochondria appear as potential primary targets. Methods: We usedapplication/pdfengGastroenterology & HepatologyBilirubin directly disrupts membrane lipid polarity and fluidity, protein order. and redox status in rat mitochondriajournal article