T follicular regulatory cells keep B cell-directed autoreactivity in check

Ribeiro, FilipaGraca, Luis2024-05-022024-05-022024Cell Res. 2024 May;34(5):339-3401001-0602http://hdl.handle.net/10451/64652© The Author(s) under exclusive licence to Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences 2024The immune system well illustrates the need for balance between aggression and tolerance: mechanisms are needed to drive the production of antibodies effective against pathogens whilst preventing the emergence of antibodies targeting our own cells. T follicular regulatory cells can suppress spontaneous antibody-mediated autoimmunity by vetoing B cell-directed reactivity.engT follicular regulatory cells keep B cell-directed autoreactivity in checkjournal article10.1038/s41422-024-00941-41748-7838