Neves, Joana B.Rodrigues, Filipe BrogueiraCastelão, MafaldaCosta, JoãoLopes, José António2020-12-172020-12-172016Journal of Critical Care Volume 33, June 2016, Pages 271-2730883-9441http://hdl.handle.net/10451/45419© 2016 Elsevier Inc. All rights reserved.Acute kidney injury (AKI) occurs frequently during hospitalization[1] and is associated with deleterious effects. The need for renal replacement therapy (RRT) in AKI is rising[4] and continuous RRT, extended daily dialysis (EDD) and intermittent haemodialysis (IHD) are the most commonly used techniques in developed countries. Previous systematic reviews and meta-analyses have investigated the use of RRT in AKI but failed to prove major outcome differences between continuous RRT and intermittent techniques, such as EDD and IHD. Hemodynamic stability and the needed rate of solute clearance guide clinical decision regarding dialytic modalities in AKI and evidence supporting the choice between IHD or EDD is limited. Therefore, we aimed to systematically review published data comparing the safety and efficacy of EDD and IHD in AKI.engjournal article10.1016/j.jcrc.2016.02.001