Lone, M.A.Santos, TâniaAlecu, I.Silva, Liana C.Hornemann, T.2025-08-152025-08-1520191388-1981http://hdl.handle.net/10400.5/102934Sphingolipids (SLs) are fundamental components of eukaryotic cells. 1-Deoxysphingolipids differ structurally from canonical SLs as they lack the essential C1-OH group. Consequently, 1-deoxysphingolipids cannot be converted to complex sphingolipids and are not degraded over the canonical catabolic pathways. Pathologically elevated 1-deoxySLs are involved in several disease conditions. Within this review, we will provide an up-to-date overview on the metabolic, physiological and pathophysiological aspects of this enigmatic class of "headless" sphingolipids.engAnimalsEukaryotaGene Regulatory NetworksHumansMolecular StructureSphingolipidsjournal article10.1016/j.bbalip.2018.12.013