Novais, FilipaLoureiro, SusanaAndrea, MafaldaFigueira, Maria LuísaPimentel, JoséPestana, Luís Câmara2021-02-012021-02-012019Laterality, 2020, Vol. 25, no. 3, 275–2841357-650Xhttp://hdl.handle.net/10451/46105© 2019 Informa UK Limited, trading as Taylor & Francis Group.The aim of this study was to determine the rate and types of lifetime psychiatric disorders, as well as their predictors, in a sample of people with refractory epilepsy. Demographic, neurological, psychiatric and neuropsychological data, from people with refractory epilepsy, were registered at the pre-surgical interview. Linear regression was used to determine predictors. One hundred and ninety-one participants were included. Forty-six percent of our sample had at least one previous psychiatric diagnosis, most frequently depressive (64%), anxiety (10%), substance use (10%) and psychotic disorders (6%). Patients with a right-side epileptogenic zone had an increased risk for these disorders (OR 2.36; CI 1.22-4.56; p = 0.01). Specific epilepsy-related factors may raise the risk of developing a psychiatric disorder. Our study adds evidence to support a bidirectional relationship between epilepsy and mental health.engRefractory epilepsyEpileptogenic zoneLateralityPsychiatric disordersjournal article10.1080/1357650X.2019.16624311464-0678