Kumar, S. PraveenGlória, Paulo M. C.Gonçalves, Lídia M.Gut, JiriRosenthal, Philip J.Moreira, RuiSantos, Maria M. M.2013-12-052013-12-052012Med. Chem. Commun., 2012, 3, 4892040-25032040-2511http://dx.doi.org/10.1039/c2md20011bhttp://hdl.handle.net/10451/9635We describe here the synthesis of a library of thirty-eight squaric derivatives and the evaluation of activity against papain-, falcipain-2- and a chloroquine-resistant strain of P. falciparum. The most active compounds combine significant antiplasmodial activity with minimal cytotoxicity.engjournal article