Swash, MichaelCarvalho, Mamede2024-05-022024-05-022024Clin Neurophysiol. 2024 May:161:242-2431388-2457http://hdl.handle.net/10451/64646© 2024 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.Fasciculations are a common early feature of amyotrophic lateral sclerosis (ALS), prompting a stream of research reports on their characteristic features based on clinical observation, surface EMG, concentric needle EMG, multipoint surface recordings, ultrasound detection within muscles, and now, MR imaging (Heskamp et al., 2024). This has revealed transient signal voids in pulsed gradient spin echo (PGSE) diffusion weighted (DW) imaging sequences, the voids representing fasciculation-associated movement of a motor unit. Fasciculations also occur, to a lesser extent in normal subjects, especially after intense exercise, and in the benign cramp/fasciculation syndrome (BFS).engjournal article10.1016/j.clinph.2024.02.0211872-8952