Perdigao, JoaoMacedo, RitaRibeiro, AnaBrum, LauraPortugal, Isabel2015-12-302015-12-302009INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. - Vol. 33, n. 4 (APR 2009), p. 334-3380924-8579http://hdl.handle.net/10451/21542Ethambutol (EMB) is a first-line antitubercular drug that inhibits arabinogalactan and lipoarabinomannan biosynthesis. Resistance to EMB has traditionally been associated with embB mutations, especially in the Met306 codon. In this study, the region encom. - Fundacao Calouste Gulbenkian, Lisbon, Portugal [FCG 001013]. - Funding: This work was supported by Fundacao Calouste Gulbenkian, Lisbon, Portugal (grant FCG 001013).application/pdfengInfectious DiseasesMicrobiologyPharmacology & PharmacyGenetic characterisation of the ethambutol resistance-determining region in Mycobacterium tuberculosisprevalence and significance of embB306 mutationsjournal articlehttp://dx.doi.org/10.1016/j.ijantimicag.2008.09.021