Luis, Paula B. M.Ruiter, Jos P. N.Aires, Catia C. P.Soveral, Gracade Almelda, Isabel TavaresDuran, MarinusWanders, Ronald J. A.Silva, Margarida F. B.2015-12-302015-12-302007BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. - Vol. 1767, n. 9 (SEP 2007), p. 1126-11330005-2728http://hdl.handle.net/10451/21625The effect of the antiepileptic drug valproic acid (VPA) on mitochondrial oxidative phosphorylation (OXPHOS) was investigated in vitro. Two experimental approaches were used, in the presence of selected respiratory-chain Substrates: (1) formation of ATP iapplication/pdfengBiochemistry & Molecular BiologyBiophysicsValproic acid metabolites inhibit dihydrolipoyl dehydrogenase activity leading to impaired 2-oxoglutarate-driven oxidative phosphorylationjournal articlehttp://dx.doi.org/10.1016/j.bbabio.2007.06.007