Baptista, A.Bianchi, L.De Groote, J.Desmet, V. J.Ishak, K. G.Korb, G.MacSween, R. N.Popper, H.Poulsen, H.Scheuer, P. J.2020-11-182020-11-181988-06Histopathology. 1988 Jun;12(6):569-791365-2559http://hdl.handle.net/10451/44917Copyright © John Wiley & Sons, Inc. All rights reserved.In this review the several types of cell damage and cell death which may be found in liver biopsy specimens are defined. We describe the different processes which occur at the portal/parenchymal or septal/parenchymal interface, viz. periportal spillover, periportal hepatitis, classic or lymphocytic piecemeal necrosis and biliary piecemeal necrosis. The diagnostic implications of these lesions in relation to the clinicopathological diagnosis and prognosis in various liver diseases are discussed.engAcute and chronic liver diseaseLiver cell necrosisPeriportal spilloverPeriportal hepatitisPiecemeal necrosisjournal article10.1111/j.1365-2559.1988.tb01982.x0309-0167