Osteosarcoma pathogenesis leads the way to new target treatments

Fernandes, IsabelAlvim, CeciliaBrás, RaquelEsperança Martins, MiguelCosta, Luis2022-09-292022-09-292021Int J Mol Sci. 2021 Jan 15;22(2):8131661-6596http://hdl.handle.net/10451/54630© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Osteosarcoma (OS) is a rare condition with very poor prognosis in a metastatic setting. Basic research has enabled a better understanding of OS pathogenesis and the discovery of new potential therapeutic targets. Phase I and II clinical trials are already ongoing, with some promising results for these patients. This article reviews OS pathogenesis and new potential therapeutic targets.engMolecular targetsOsteosarcomaPathogenesisOsteosarcoma pathogenesis leads the way to new target treatmentsjournal article10.3390/ijms220208131422-0067