Henriques-Calado, JoanaDuarte-Silva, Maria EugéniaFerreira, Ana Sousa2024-04-022024-04-022018-08-08Henriques-Calado, J., Duarte-Silva, M. E., & Ferreira, A. S. (2018). Depressive vulnerability in women with Alzheimer's disease: Relationship with personality traits and abnormal personality dimensions. Journal of affective disorders, 241, 182-191. https://doi.org/10.1016/j.jad.2018.08.0040165-0327http://hdl.handle.net/10451/63872Background: This study sought to determine the evaluation of current and pre-morbid depressive vulnerability dimensions in Alzheimer's disease. Sidney Blatt´s personality developmental perspective, the Five-Factor model and Axis II personality disorders were taken as references. Methods: The study was conducted with two groups which were assessed using the Depressive Experiences Questionnaire, the NEO-FFI and the Personality Diagnostic Questionnaire-4+, in the form of individual interview sessions. Current personality measure: Alzheimer's disease Group, consisting of 44 female participants (M Age= 81.36 years); Pre-morbid personality measure: Alzheimer's disease Group Informants (n = 40). Results: Self-Criticism personality vulnerability is a general indicator of psychopathology. In pre-morbidity, Neuroticism (β = 0.41), Agreeableness (β = −0.63) and Conscientiousness (β = -0.08) predicted Self-Criticism, explaining 64% of the variance; additionally, Self-Criticism (β = 0.72) and Neediness (β = 2.05) predicted the PDQ-4+ total, explaining 58% of the variance. In terms of current personality, the PDQ-4+ total was predicted by Self-Criticism (β = 0.55), explaining 30% of the variance. Limitations: The small size of the samples, especially since it is difficult to access individuals diagnosed with AD at the onset or in its early stages; measuring personality changes by means of retrospective assessment by proxies may have introduced some memory bias. Conclusions: These findings are relevant to research relating depressive vulnerability to personality traits and psychopathology in Alzheimer's disease.engAlzheimer's diseasePersonalityFive-factor modelPsychopathologyDepressive vulnerabilityPsychodynamicjournal article2024-02-04cv-prod-65294010.1016/j.jad.2018.08.004000443816800025