Saldanha, C.2014-03-042014-03-042013Clinical Hemorheology and Microcirculation 53 (2013) 39–441386-0291http://dx.doi.org/10.3233/CH-2012-1574http://hdl.handle.net/10451/10673© 2013 – IOS Press and the authors. All rights reservedA brief review of the fibrinogen molecule composition and structure is presented like as an introduction to the effects of this plasma protein on the red blood cell hemorheoplogical properties namely erythrocyte aggregation tendency and deformability ability. The protein membrane RBC target for fibrinogen is also highlight as well as the erythrocyte signal transduction pathway associated with nitric oxide mobilization resulting from its binding.engFibrinogenNitric oxideCD47Erythrocyte aggregationErythrocte deformabilityjournal article