Ministro, AugustoPereira, RitaPinto, VandaSantos, Susana Constantino RosaPedro, Luis2019-11-252019-11-252019Journal of Vascular Surgery, Volume 70, Issue 5, e122 - e1230741-5214http://hdl.handle.net/10451/40251© 2019 Published by Elsevier Inc.Objective: Low-dose ionizing radiation (LDIR), namely, 0.3 Gy, delivered during 4 consecutive days, has been reported to stimulate angiogenesis and arteriogenesis in a preclinical model of hindlimb ischemia. Here we performed a single-center, investigator-blinded, randomized, shamcontrolled clinical trial to evaluate the effects of LDIR exposure in the expression of proangiogenic genes in endothelial cells isolated from muscles of patients with critical limb ischemia.engjournal article10.1016/j.jvs.2019.08.038