Martins e Silva, JoãoSaldanha, Carlota2020-10-262020-10-261986Acta Médica Portuguesa 1986; 7: 63-640870-399Xhttp://hdl.handle.net/10451/44659Revista Científica da Ordem dos Médicos, Copyright © Ordem dos Médicos 2020.In addition to the suggestive involvement of the noradrenergic system, there is substantial evidence that blood pressure regulation in the man and some other mammais (e.g.cat, dog and rat) is dependent on the cholinergic activity. Many experimental and some clinical studies have demonstrated that the stimulation of the central cholinergic system by direct receptor agonists or acetylcholinesterase (AChE) inhibitors, mediates a rise in arterial pressure.engjournal article1646-0758