Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-beta 1-induced apoptosis in rat hepatocytes

Sola, SAmaral, JCastro, RERamalho, RMBorralho, PMKren, BTTanaka, HSteer, CJRodrigues, CMP2015-12-302015-12-302005HEPATOLOGY. - Vol. 42, n. 4 (OCT 2005), p. 925-9340270-9139http://hdl.handle.net/10451/21504Ursodeoxycholic acid (UDCA) inhibits classical mitochondrial pathways of apoptosis by either directly stabiliz* mitochondrial membranes or modulating specific upstream targets. Furthermore, UDCA regulates apoptosis-related genes from transforming growth fapplication/pdfengGastroenterology & HepatologyNuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-beta 1-induced apoptosis in rat hepatocytesjournal articlehttp://dx.doi.org/10.1002/hep.20870