Murray, JohnRibeiro, Ruy M.2020-12-022020-12-022018Viruses 2018, 10, 303http://hdl.handle.net/10451/45066© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).How an infection will progress in the body is dependent on myriad factors: the rate of spread of the agent, the immune response, what treatment may be applied, .... Clinically following the progression of the disease is limited to snapshots at discrete time points (longitudinally in an individual or in an in vitro/animal model if that is available, but most often from cross-sectional data over cohorts of individuals), and in many cases the data obtained are from a body compartment that is not the site of replication of the disease.engHumansViremiaModels, theoreticalVirus diseasesjournal article10.3390/v100603031999-4915