Differential effect of valproate and its Delta(2)- and Delta(4)-unsaturated metabolites, on the beta-oxidation rate of long-chain and medium-chain fatty acids

Silva, MFBRuiter, JPNIJlst, LJakobs, CDuran, Mde Almeida, ITWanders, RJA2015-12-302015-12-302001CHEMICO-BIOLOGICAL INTERACTIONS. - Vol. 137, n. 3 (SEP 28 2001), p. 203-2120009-2797http://hdl.handle.net/10451/21331Overall fatty acid oxidation rates were investigated in rat hepatocytes using [9,10-H-3]palmitic, [9,10-H-3]-oleic, [9.10-H-3]-myristic and [2,3-H-3]-phenylpropionic acids. The effect of both valproate (VPA) (0-10 mM) and two of its unsaturated metaboliteapplication/pdfengBiochemistry & Molecular BiologyPharmacology & PharmacyToxicologyDifferential effect of valproate and its Delta(2)- and Delta(4)-unsaturated metabolites, on the beta-oxidation rate of long-chain and medium-chain fatty acidsjournal article