Ursodeoxycholic acid modulates E2F-1 and p53 expression through a caspase-independent mechanism in transforming growth factor beta 1-induced apoptosis of rat hepatocytes

Sola, SMa, XMCastro, REKren, BTSteer, CJRodrigues, CMP2015-12-302015-12-302003JOURNAL OF BIOLOGICAL CHEMISTRY. - Vol. 278, n. 49 (DEC 5 2003), p. 48831-488380021-9258http://hdl.handle.net/10451/21065Transforming growth factor beta1 (TGF-beta1)-induced hepatocyte apoptosis is associated with activation of E2F transcription factors and p53 stabilization through Mdm-2, thus potentially modulating a number of target genes. In previous studies, we have shapplication/pdfengBiochemistry & Molecular BiologyUrsodeoxycholic acid modulates E2F-1 and p53 expression through a caspase-independent mechanism in transforming growth factor beta 1-induced apoptosis of rat hepatocytesjournal articlehttp://dx.doi.org/10.1074/jbc.M300468200