Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors

Clemente, ADomingos, AGrancho, APIley, JMoreira, RNeres, JPalma, NSantana, ABValente, E2015-12-302015-12-302001BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - Vol. 11, n. 8 (APR 23 2001), p. 1065-10680960-894Xhttp://hdl.handle.net/10451/21168A series of N-acyloxymethyl- and N-aminocarbonyloxymethyl derivatives of 2-azetidinones. 3, with different substituent patterns at the beta -lactam C-3 and C-4 positions, were designed as potential mechanism-based inhibitors for human leukocyte elastase and found to exhibit inhibitory potency and selectivity for the enzyme, (C) 2001 Elsevier Science Ltd. All rights reserved.application/pdfengChemistry, MedicinalChemistry, OrganicDesign, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitorsjournal article