1. Repositório da Universidade de Lisboa
  2. Comunidades & Colecções
  3. Instituto de Medicina Molecular João Lobo Antunes (iMM)
  4. IMM - Artigos em Revistas Internacionais
Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/54178
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degois.publication.firstPage221pt_PT
degois.publication.issue2pt_PT
degois.publication.lastPage226pt_PT
degois.publication.titleMedChemCommpt_PT
dc.relation.publisherversionhttps://pubs.rsc.org/en/journals/journalissues/md#!recentarticles&advpt_PT
dc.contributor.authorAguiar, Luísa-
dc.contributor.authorMachado, Marta-
dc.contributor.authorSanches-Vaz, Margarida-
dc.contributor.authorPrudêncio, Miguel-
dc.contributor.authorVale, Nuno-
dc.contributor.authorGomes, Paula-
dc.date.accessioned2022-08-24T11:33:42Z-
dc.date.available2022-08-24T11:33:42Z-
dc.date.issued2019-
dc.identifier.citationMedchemcomm. 2018 Nov 16;10(2):221-226pt_PT
dc.identifier.issn2040-2511-
dc.identifier.urihttp://hdl.handle.net/10451/54178-
dc.descriptionThis journal is © The Royal Society of Chemistry 2018pt_PT
dc.description.abstractNovel primaquine-cell penetrating peptide conjugates were synthesised and tested in vitro against liver stage Plasmodium berghei parasites. Generally, the conjugates were more active than the parent peptides and, in some cases, than the parent drug. These are unprecedented findings that may open a new route towards antimalarial drug rescuing.pt_PT
dc.description.sponsorshipThe authors are indebted to Fundação para a Ciência e Tecnologia (FCT, Portugal) for funding LAQV-REQUIMTE re- search unit through project UID/QUI/50006/2013. NV thanks FCT and FEDER (European Union) for funding project IF/00092/2014/CP1255/CT0004 and IF position. LA thanks FCT and the Medicinal Biochemistry and Biochemistry International Doctoral Programme (M2B-PhD) for PhD grant PD/BD/106035/2015.pt_PT
dc.language.isoengpt_PT
dc.publisherRoyal Society of Chemistrypt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F50006%2F2013/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00092%2F2014%2FCP1255%2FCT0004/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT//PD%2FBD%2F106035%2F2015/PTpt_PT
dc.rightsrestrictedAccesspt_PT
dc.titleCoupling the cell-penetrating peptides transportan and transportan 10 to primaquine enhances its activity against liver-stage malaria parasitespt_PT
dc.typearticlept_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.peerreviewedyespt_PT
degois.publication.volume10pt_PT
dc.identifier.doi10.1039/C8MD00447Apt_PT
Aparece nas colecções:FM - Artigos em Revistas Internacionais
IMM - Artigos em Revistas Internacionais

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