An artificial CO-releasing metalloprotein built by histidine-selective metallation

Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/53200

Título:	An artificial CO-releasing metalloprotein built by histidine-selective metallation
Autor:	Albuquerque, Inês S. Jeremias, Hélia F. Chaves-Ferreira, Miguel Matak-Vinkovic, Dijana Boutureira, Omar Romão, Carlos C. Bernardes, Gonçalo J. L.
Data:	2015
Editora:	Royal Society of Chemistry
Citação:	Chem Commun (Camb). 2015 Mar 7;51(19):3993-3996
Resumo:	We report the design and synthesis of an aquacarbonyl Ru(II) dication cis-[Ru(CO)2(H2O)4](2+) reagent for histidine (His)-selective metallation of interleukin (IL)-8 at site 33. The artificial, non-toxic interleukin (IL)-8-Ru(II)(CO)2 metalloprotein retained IL-8-dependent neutrophil chemotactic activity and was shown to spontaneously release CO in live cells.
Descrição:	This journal is © The Royal Society of Chemistry 2015. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.
Peer review:	yes
URI:	http://hdl.handle.net/10451/53200
DOI:	10.1039/C4CC10204E
ISSN:	1359-7345
Versão do Editor:	https://pubs.rsc.org/en/journals/journalissues/cc#!recentarticles&adv
Aparece nas colecções:	FM - Artigos em Revistas Internacionais IMM - Artigos em Revistas Internacionais

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