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http://hdl.handle.net/10451/47252| Título: | A distinct neuromelanin magnetic resonance imaging pattern in parkinsonian multiple system atrophy |
| Autor: | Simões, Rita Moiron Castro Caldas, Ana Grilo, Joana Correia, Daisy Guerreiro, Carla Pita Lobo, Patrícia Valadas, Anabela Fabbri, Marguerita Correia Guedes, Leonor Coelho, Miguel Rosa, Mário Miguel Ferreira, Joaquim J Reimão, Sofia |
| Palavras-chave: | MRI Multiple system atrophy Neuromelanin Nigrosome 1 Susceptibility-weighted imaging |
| Data: | 2020 |
| Editora: | Springer Nature |
| Citação: | BMC Neurol. 2020 Nov 27;20(1):432 |
| Resumo: | Background: Parkinsonian variant of multiple system atrophy is a neurodegenerative disorder frequently misdiagnosed as Parkinson's disease. No early imaging biomarkers currently differentiate these disorders. Methods: Simple visual imaging analysis of the substantia nigra and locus coeruleus in neuromelanin-sensitive magnetic resonance imaging and nigrosome 1 in susceptibility-weighted sequences was performed in thirty patients with parkinsonian variant of multiple system atrophy fulfilling possible/probable second consensus diagnostic criteria. The neuromelanin visual pattern was compared to patients with Parkinson's disease with the same disease duration (n = 10) and healthy controls (n = 10). Substantia nigra semi-automated neuromelanin area/signal intensity was compared to the visual data. Results: Groups were similar in age, sex, disease duration, and levodopa equivalent dose. Hoehn & Yahr stage was higher in parkinsonian multiple system atrophy patients, 69% of whom had normal neuromelanin size/signal, significantly different from Parkinson's disease patients, and similar to controls. Nigrosome 1 signal was lost in 74% of parkinsonian multiple system atrophy patients. Semi-automated neuromelanin substantia nigra signal, but not area, measurements were able to differentiate groups. Conclusions: In patients with parkinsonism, simple visual magnetic resonance imaging analysis showing normal neuromelanin substantia nigra and locus coeruleus, combined with nigrosome 1 loss, allowed the distinction of the parkinsonian variant of multiple system atrophy from Parkinson's disease and healthy controls. This easy and widely available method was superior to semi-automated measurements in identifying specific imaging changes in substantia nigra and locus coeruleus. |
| Descrição: | © The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
| Peer review: | yes |
| URI: | http://hdl.handle.net/10451/47252 |
| DOI: | 10.1186/s12883-020-02007-5 |
| Versão do Editor: | https://bmcneurol.biomedcentral.com/ |
| Aparece nas colecções: | FM - Artigos em Revistas Internacionais IMM - Artigos em Revistas Internacionais |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| Distinct_neuromelanin.pdf | 2,86 MB | Adobe PDF | Ver/Abrir |
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