Utilize este identificador para referenciar este registo:
http://hdl.handle.net/10451/32815| Título: | Antibody approaches to treat brain diseases |
| Autor: | Neves, Vera Silva, Frederico Aires da Real, Sofia Corte Castanho, Miguel A. R. B. |
| Data: | 2016 |
| Editora: | Elsevier |
| Citação: | Trends in Biotechnology, January 2016, Vol. 34, No. 1 |
| Resumo: | Recombinant antibodies are an emerging class of therapeutics with substantial promise to treat central nervous system (CNS) diseases such as Alzheimer's, Parkinson's, stroke, and brain cancers. However, poor blood–brain barrier (BBB) permeability hinders the progress of antibody therapies for conditions in which the target is located in the brain. Nonetheless, antibodies can nowa-days be engineered to enhance their therapeutic applications and translocation of the BBB using the natural portals of the brain. This paper reviews advances in the development and engineering of therapeutic BBB-crossing antibodies and their high potential for treatment of CNS disorders. |
| Descrição: | © 2015 Elsevier Ltd. |
| Peer review: | yes |
| URI: | http://hdl.handle.net/10451/32815 |
| DOI: | 10.1016/j.tibtech.2015.10.005 |
| ISSN: | 0167-7799 |
| Versão do Editor: | https://www.journals.elsevier.com/trends-in-biotechnology |
| Aparece nas colecções: | IMM - Artigos em Revistas Internacionais |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| Antibody_brain.pdf | 2,18 MB | Adobe PDF | Ver/Abrir Acesso Restrito. Solicitar cópia ao autor! | |
| 32815_FREE_Post-Print.pdf | 1,67 MB | Adobe PDF | Ver/Abrir |
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