Abietanes from Plectranthus grandidentatus and P-hereroensis against methicillin- and vancomycin-resistant bacteria

Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/21347

Título:	Abietanes from Plectranthus grandidentatus and P-hereroensis against methicillin- and vancomycin-resistant bacteria
Autor:	Gaspar-Marques, C Rijo, P Simeoes, MF Duarte, MA Rodriguez, B
Palavras-chave:	Plant Sciences Chemistry, Medicinal Pharmacology & Pharmacy
Data:	2006
Editora:	ELSEVIER GMBH, URBAN & FISCHER VERLAG
Citação:	PHYTOMEDICINE. - Vol. 13, n. 4 (MAR 2006), p. 267-271
Resumo:	The antimicrobial activity of 10 natural abietanes isolated from Plectranthus grandidentatus and P. hereroensis acetonic extract was evaluated against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VRE). The results revealed that the most active diterpenes were coleon U (1), 7 alpha-acetoxy-6 beta-hydroxyroyleanone (2) and horminone (3). Minimum inhibitory concentration (MIC) values ranging 0.98-15.63 mu g/ml were obtained for MRSA clinical strains, and MIC values of 15.63 and 31.25 mu g/ml were obtained for VRE clinical strains. Some structure-activity relationships are emphasized. (c) 2005 Elsevier GmbH. All rights reserved.
URI:	http://hdl.handle.net/10451/21347
DOI:	http://dx.doi.org/10.1016/j.phymed.2005.06.002
ISSN:	0944-7113
Aparece nas colecções:	FF - Produção Científica 2000-2009

Ficheiros deste registo:

Não existem ficheiros associados a este registo.