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Authors
Abstract(s)
Esta monografia apresenta de forma resumida o novo coronavírus SARS-CoV-2 e a doença por si provocada (COVID-19). Neste contexto, faz-se uma breve apresentação das características do vírus, da fisiopatologia e epidemiologia da doença.
De acordo com as potenciais terapêuticas a aplicar no tratamento da COVID-19, o trabalho está centrado na terapêutica com surfactantes pulmonares. Deste modo, faz-se uma breve apresentação dos surfactantes, nomeadamente da classificação química dos mesmos.
Relativamente aos surfactantes pulmonares apresentam-se as suas principais características e aplicações terapêuticas.
Das várias abordagens terapêuticas discutem-se os benefícios e riscos dos surfactantes pulmonares. Estes não apresentam efeito profilático, nem eliminam o vírus, mas demonstram eficácia terapêutica associada a uma melhoria da capacidade respiratória dos doentes e consequentemente diminuem a necessidade da respiração assistida por ventiladores, assim como estão associados a uma diminuição da taxa de mortalidade.
This monograph briefly presents the new coronavirus SARS-CoV-2 and the disease it causes (COVID-19). In this context, this monograph shows a brief presentation of the virus's characteristics and the disease's pathophysiology and epidemiology. According to the potential therapies to be applied in the treatment of COVID-19, the main focus is pulmonary surfactant therapy. Thus, the surfactants are discussed, namely their chemical classification. The main characteristics and therapeutic applications of pulmonary surfactants are also described. It also presents the benefits and risks of pulmonary surfactants among the various therapeutic approaches. These do not have a prophylactic effect, nor do they eliminate the virus, but demonstrate therapeutic efficacy associated with an improvement in the respiratory capacity of patients and consequently reduce the need for ventilator-assisted breathing, as well as being associated with a decrease in the mortality rate.
This monograph briefly presents the new coronavirus SARS-CoV-2 and the disease it causes (COVID-19). In this context, this monograph shows a brief presentation of the virus's characteristics and the disease's pathophysiology and epidemiology. According to the potential therapies to be applied in the treatment of COVID-19, the main focus is pulmonary surfactant therapy. Thus, the surfactants are discussed, namely their chemical classification. The main characteristics and therapeutic applications of pulmonary surfactants are also described. It also presents the benefits and risks of pulmonary surfactants among the various therapeutic approaches. These do not have a prophylactic effect, nor do they eliminate the virus, but demonstrate therapeutic efficacy associated with an improvement in the respiratory capacity of patients and consequently reduce the need for ventilator-assisted breathing, as well as being associated with a decrease in the mortality rate.
Description
Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, 2022, Universidade de Lisboa, Faculdade de Farmácia.
Keywords
COVID-19 SARS-CoV-2 Surfactante pulmonar Células alveolares tipo II Terapia com surfactantes Mestrado integrado - 2022