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Publication
Evasão bacteriana ao sistema do complemento
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Advisor(s)
Abstract(s)
Um dos aspetos mais importantes do Sistema imunitário inato é a atividade bactericida intrínseca ao Complemento. Este representa uma primeira linha de defesa com particular relevância e eficácia na ativação direta e imediata após a invasão sistémica por um potencial patógeno. No entanto, vários agentes patogénicos encontraram mecanismos que lhes permitem evadir e contornar a ação do complemento. Como tal, torna-se pertinente uma descrição geral dos vários mecanismos utilizados na evasão ao Sistema do Complemento, tanto por bactérias Gram-positivas como por bactérias Gram-negativas. Estes mecanismos podem ser separados em três grandes grupos, nomeadamente, o recrutamento de reguladores da ativação do Complemento provenientes do Hospedeiro, a inativação por clivagem enzimática e a inibição e/ou modulação da ativação do Complemento por interação direta com proteínas bacterianas. Dentro de cada um destes grupos são dados os exemplos mais relevantes e pertinentes das espécies bacterianas que os utilizam como forma de escape ao Complemento.
One of the most important aspects of the innate immune system is the bactericidal activity intrinsic to the Complement. It is the first line of defense representing a particularly relevant and effective defense system which is immediately and directly activated upon entry of a pathogen. However, several pathogens have found mechanisms that allow them to evade and bypass the action of the complement. As such, it becomes necessary a general description of the various mechanisms used to evade the Complement System, both by Gram-positive bacteria and by Gram-negative bacteria. These mechanisms can be separated into three major groups, namely recruitment of Complement activation regulators from the host, inactivation by enzymatic cleavage and inhibition and / or modulation of complement activation by direct interaction with bacterial proteins. Within each of these groups are given the most relevant examples of the bacterial species that use them as a way of escaping the Complement.
One of the most important aspects of the innate immune system is the bactericidal activity intrinsic to the Complement. It is the first line of defense representing a particularly relevant and effective defense system which is immediately and directly activated upon entry of a pathogen. However, several pathogens have found mechanisms that allow them to evade and bypass the action of the complement. As such, it becomes necessary a general description of the various mechanisms used to evade the Complement System, both by Gram-positive bacteria and by Gram-negative bacteria. These mechanisms can be separated into three major groups, namely recruitment of Complement activation regulators from the host, inactivation by enzymatic cleavage and inhibition and / or modulation of complement activation by direct interaction with bacterial proteins. Within each of these groups are given the most relevant examples of the bacterial species that use them as a way of escaping the Complement.
Description
Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2019
Keywords
Complemento evasão bactérias recrutamento reguladores Mestrado Integrado - 2019