Publicação
Process Intensification for the Synthesis of 6-Allyl-6-azabicyclo[3.1.0]hex-3-en-2-ol from 1-Allylpyridinium Salt Using a Continuous UV-Light Photoflow Approach
| dc.contributor.author | Fortunato, Milene | |
| dc.contributor.author | Ly, Chi-Phong | |
| dc.contributor.author | Siopa, Filipa | |
| dc.contributor.author | Afonso, Carlos | |
| dc.date.accessioned | 2023-09-14T14:52:15Z | |
| dc.date.available | 2023-09-14T14:52:15Z | |
| dc.date.issued | 2019-08-05 | |
| dc.date.updated | 2023-02-23T10:55:44Z | |
| dc.description | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | pt_PT |
| dc.description.abstract | A new home-made UV photochemical reactor (95 cm of irradiation zone) consisting of a 12 parallel quartz tubes flow reactor, PQT6 (95 cm under irradiation and an internal diameter of 0.6 cm) was assembled to perform photochemical transformations in continuous-flow. PQT6 was evaluated for the photoreaction of 1-allylpyridinium bromide (1a) to 6-allyl-6-azabicyclo[3.1.0]hex-3-en-2-ol (2a), in a continuous process. This technology provides reduced reaction times, continuous production of 2a, and a productivity of 129 mg h−1, corresponding to 1.94 g of isolated 2a after 15 h of irradiation. | pt_PT |
| dc.description.sponsorship | This research was funded by Fundação para a Ciência e a Tecnologia (FCT) (ref. PTDC/QUI-QOR/32008/2017, UID/DTP/04138/2013, PESSOA 2018/2019 (Proc. 441.00 França and PHC PESSOA 2018 No 40875QJ)) and European Research Area Network; ERANet LAC (ref. ELAC2014/BEE-0341). | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Fortunato MAG, Ly C-P, Siopa F, Afonso CAM. Process Intensification for the Synthesis of 6-Allyl-6-azabicyclo[3.1.0]hex-3-en-2-ol from 1-Allylpyridinium Salt Using a Continuous UV-Light Photoflow Approach. Methods and Protocols [Internet]. 2019 Aug 5;2(3):67. Available from: http://dx.doi.org/10.3390/mps2030067 | pt_PT |
| dc.identifier.doi | 10.3390/mps2030067 | pt_PT |
| dc.identifier.slug | cv-prod-1102369 | |
| dc.identifier.uri | http://hdl.handle.net/10451/59299 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | MDPI | pt_PT |
| dc.relation | PTDC/QUI-QOR/32008/2017 | pt_PT |
| dc.relation | UID/DTP/04138/2013 | pt_PT |
| dc.relation.publisherversion | https://www.mdpi.com/2409-9279/2/3/67 | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | flow reaction | pt_PT |
| dc.subject | photochemistry | pt_PT |
| dc.subject | bicyclic aziridine | pt_PT |
| dc.title | Process Intensification for the Synthesis of 6-Allyl-6-azabicyclo[3.1.0]hex-3-en-2-ol from 1-Allylpyridinium Salt Using a Continuous UV-Light Photoflow Approach | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 3 | pt_PT |
| oaire.citation.startPage | 67 | pt_PT |
| oaire.citation.title | Methods and Protocols | pt_PT |
| oaire.citation.volume | 2 | pt_PT |
| person.familyName | Gamito Fortunato | |
| person.familyName | Deslgado Siopa | |
| person.familyName | Mateus Afonso | |
| person.givenName | Milene Andreia | |
| person.givenName | Filipa Alexandra | |
| person.givenName | Carlos Alberto | |
| person.identifier.ciencia-id | AA16-A885-3ABD | |
| person.identifier.ciencia-id | 6A16-150F-A9F9 | |
| person.identifier.ciencia-id | 6319-2E4C-5BE1 | |
| person.identifier.orcid | 0000-0003-1072-0709 | |
| person.identifier.orcid | 0000-0002-4514-9154 | |
| person.identifier.orcid | 0000-0002-7284-5948 | |
| rcaap.cv.cienciaid | 6A16-150F-A9F9 | Filipa Alexandra Delgado Siopa | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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