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Variation and Selection in the Putative Sperm-Binding Region of ZP3 in Muroid Rodents: A Comparison between Cricetids and Murines

2021-09Journal article Open access
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dc.contributor.authorDuarte, Margarida Alexandra
dc.contributor.authorFernandes, C
dc.contributor.authorHeckel, Gerald
dc.contributor.authorda Luz Mathias, Maria
dc.contributor.authorBastos-Silveira, Cristiane
dc.date.accessioned2021-09-28T15:57:23Z
dc.date.available2021-09-28T15:57:23Z
dc.date.issued2021-09
dc.description.abstractIn mammals, the zona pellucida glycoprotein 3 (ZP3) is considered a primary sperm receptor of the oocyte and is hypothesized to be involved in reproductive isolation. We investigated patterns of diversity and selection in the putative sperm-binding region (pSBR) of mouse ZP3 across Cricetidae and Murinae, two hyperdiverse taxonomic groups within muroid rodents. In murines, the pSBR is fairly conserved, in particular the serine-rich stretch containing the glycosylation sites proposed as essential for sperm binding. In contrast, cricetid amino acid sequences of the pSBR were much more variable and the serine-rich motif, typical of murines, was generally substantially modified. Overall, our results suggest a general lack of species specificity of the pSBR across the two muroid families. We document statistical evidence of positive selection acting on exons 6 and 7 of ZP3 and identified several amino acid sites that are likely targets of selection, with most positively selected sites falling within or adjacent to the pSBR.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDuarte, M.A.; Fernandes, C.R.; Heckel, G.; da Luz Mathias, M.; Bastos-Silveira, C. Variation and Selection in the Putative Sperm-Binding Region of ZP3 in Muroid Rodents: A Comparison between Cricetids and Murines. Genes 2021, 12, 1450. https://doi.org/ 10.3390/genes12091450pt_PT
dc.identifier.doi10.3390/genes12091450pt_PT
dc.identifier.issn2073-4425
dc.identifier.urihttp://hdl.handle.net/10451/49666
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationSwiss National Science Foundation Grant 31003A-149585pt_PT
dc.relationSwiss National Science Foundation Grant 176209pt_PT
dc.relationFCT UID/BIA/00329/2020pt_PT
dc.relationUnderstanding the origin and persistence of Microtus species in the Iberian Peninsula: the genetical, behavior and ecological forces.
dc.relationCentre for Environmental and Marine Studies
dc.relation.publisherversionhttps://www.mdpi.com/2073-4425/12/9/1450/htmpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectzona pellucida glycoprotein 3pt_PT
dc.subjectsperm receptorpt_PT
dc.subjectfemale fertilization proteinpt_PT
dc.subjectpositive selectionpt_PT
dc.subjectCricetidaept_PT
dc.subjectMurinaept_PT
dc.titleVariation and Selection in the Putative Sperm-Binding Region of ZP3 in Muroid Rodents: A Comparison between Cricetids and Murinespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleUnderstanding the origin and persistence of Microtus species in the Iberian Peninsula: the genetical, behavior and ecological forces.
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/30858/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/59924/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-BEC%2F103729%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/157405/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FAMB%2F50017%2F2013/PT
oaire.citation.startPage1450pt_PT
oaire.citation.titleGenespt_PT
oaire.citation.volume12pt_PT
oaire.fundingStreamOE
oaire.fundingStreamOE
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFernandes
person.familyNameBastos-Silveira
person.givenNameCarlos
person.givenNameCristiane
person.identifier.ciencia-idF413-49F5-CA96
person.identifier.orcid0000-0002-1386-8103
person.identifier.orcid0000-0001-8249-9383
person.identifier.ridJ-3045-2013
person.identifier.scopus-author-id8966321900
person.identifier.scopus-author-id14059443700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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