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Brain-derived neurotrophic factor modulation in response to oxidative stress and corticosterone: role of scopolamine and mirtazapine

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dc.contributor.authorCorreia, Ana Salomé
dc.contributor.authorTorrado, Marília
dc.contributor.authorCosta-Coelho, Tiago
dc.contributor.authorCarvalho, Eva Daniela
dc.contributor.authorInteiro-Oliveira, Sara
dc.contributor.authorDiógenes, Maria José
dc.contributor.authorPêgo, Ana Paula
dc.contributor.authorSantos, Sofia Duque
dc.contributor.authorSebastião, Ana M
dc.contributor.authorVale, Nuno
dc.date.accessioned2025-06-11T14:59:36Z
dc.date.available2025-06-11T14:59:36Z
dc.date.issued2024
dc.description© 2024 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractMajor Depressive Disorder (MDD) is a very complex disease, challenging to study and manage. The complexities of MDD require extensive research of its mechanisms to develop more effective therapeutic approaches. Crucial in the context of this disease is the role of brain-derived neurotrophic factor (BDNF) signaling pathway. Aim: This manuscript aims to explore the complex relationship between MDD and BDNF signaling pathway, focusing on how BDNF is modulated in response to oxidative stress and corticosterone, known to be altered in MDD and contributing to the pathology of the disorder, when treated with scopolamine and mirtazapine. Methods: To assess BDNF levels after the different treatment conditions, rat hippocampal slices and mice primary hippocampus and cortical cell culture were analyzed by immunofluorescence and Western blot. Key findings: Both mirtazapine and scopolamine under stress conditions induced by hydrogen peroxide (H2O2) and corticosterone, had a significant impact on BDNF levels, and this was distinct in different neuronal models. Mirtazapine, especially when combined with H2O2, altered BDNF expression. Scopolamine when combined with both stressors also altered BDNF levels. However, its effects varied depending on the specific neuronal model and stress condition. In accordance with BDNF results, phosphorylated tropomyosin receptor kinase B (pTrkB) presented increased activation when neuronal cells subjected to stress were treated with mirtazapine or scopolamine. Significance: Collectively, this study highlights the complex connection between these compounds, stress conditions, and BDNF/TrkB modulation, supporting the potential therapeutic effects of scopolamine and mirtazapine in modulating BDNF levels, even in stressful conditions.pt_PT
dc.description.sponsorshipThis article was supported by National Funds through FCT—Fundação para a Ciência e a Tecnologia, I.P., within CINTESIS, R&D Unit (reference UIDB/4255/2020). Ana Salomé Correia acknowledges FCT for funding her PhD grant (SFRH/BD/146093/2019), Marília Torrado for FCT SFRH/BD/146754/2019, Tiago Costa-Coelho for 2022.10594.BD, Eva Carvalho for SFRH/BD/140363/2018 and Sofia Santos for 10.54499/DL57/2016/CP1360/CT0013.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLife Sci. 2024 Dec 1:358:123133pt_PT
dc.identifier.doi10.1016/j.lfs.2024.123133pt_PT
dc.identifier.eissn1879-0631
dc.identifier.issn0024-3205
dc.identifier.urihttp://hdl.handle.net/10400.5/101501
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationUIDB/4255/2020pt_PT
dc.relationDETOX: an innovative neuroprotective nanosystem for the treatment of cerebrovascular accidents
dc.relationNot Available
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/life-sciencespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBrain-derived neurotrophic factorpt_PT
dc.subjectCorticosteronept_PT
dc.subjectGlucocorticoidspt_PT
dc.subjectHypothalamic–pituitary–adrenal axispt_PT
dc.subjectMajor depressive disorderpt_PT
dc.subjectMirtazapinept_PT
dc.subjectOxidative stresspt_PT
dc.subjectScopolaminept_PT
dc.subjectTropomyosin receptor kinase Bpt_PT
dc.titleBrain-derived neurotrophic factor modulation in response to oxidative stress and corticosterone: role of scopolamine and mirtazapinept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDETOX: an innovative neuroprotective nanosystem for the treatment of cerebrovascular accidents
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F146093%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F146754%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//2022.10594.BD/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F140363%2F2018/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/DL 57%2F2016/DL 57%2F2016%2FCP1360%2FCT0013/PT
oaire.citation.titleLife Sciencespt_PT
oaire.citation.volume358pt_PT
oaire.fundingStreamPOR_NORTE
oaire.fundingStreamDL 57/2016
person.familyNameCosta-Coelho
person.familyNamede Oliveira
person.familyNamede Oliveira Diógenes Nogueira
person.familyNameSebastião
person.givenNameTiago
person.givenNameSara Inteiro
person.givenNameMaria José
person.givenNameAna M
person.identifier927187
person.identifier.ciencia-id7119-01F6-7187
person.identifier.ciencia-id5317-77BF-0B70
person.identifier.ciencia-id4B10-886B-DAFC
person.identifier.ciencia-idF112-55E8-E37E
person.identifier.orcid0000-0003-3097-6728
person.identifier.orcid0000-0002-1604-656X
person.identifier.orcid0000-0001-5486-6246
person.identifier.orcid0000-0001-9030-6115
person.identifier.scopus-author-id7004409879
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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