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Enzymes present in neutrophil extracellular traps may stimulate the fibrogenic PGF(2 alpha) pathway in the mare endometrium

2021-09-06Journal article Open access
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dc.contributor.authorRebordão, Maria Rosa
dc.contributor.authorAmaral, Ana
dc.contributor.authorFernandes, Carina
dc.contributor.authorSilva, E
dc.contributor.authorLukasik, Karolina
dc.contributor.authorSzóstek-Mioduchowska, Anna
dc.contributor.authorBravo, Pedro
dc.contributor.authorGalvão, António
dc.contributor.authorSkarzynski, Dariusz J.
dc.contributor.authorFerreira-Dias, Graça
dc.date.accessioned2021-11-03T00:11:45Z
dc.date.available2021-11-03T00:11:45Z
dc.date.issued2021-09-06
dc.descriptionResearch Areas: AgricultureVeterinary Sciencespt_PT
dc.description.abstractEndometrosis is a fibrotic disease in mare endometrium whose pathological mechanisms remain obscure. Prostaglandin (PG)F2α, despite modulating reproductive physiological processes, may also provoke local pathological collagen deposition (fibrogenesis). Neutrophil extracellular traps (NETs) released during inflammation have been linked to fibrogenesis in several tissues. We have previously shown that enzymes found in NETs increase in vitro collagen production in mare endometrium. In this study, activation of PGF2α-pathway in equine endometrial explants challenged in vitro by enzymes found in NETs is shown. Our results indicate that both endocrine microenvironment (estrous cycle phase) and healthy or pathological conditions of endometrial tissues play an important role in PGF2α-pathway activation. In the endometrium of the follicular phase, we have observed both high production of PGF2α and/or PGF2α receptor gene transcription under the action of enzymes found in NETs, both conditions associated with fibrogenesis in other tissues. Nevertheless, transcription of the PGF2α receptor gene does not appear to be hormone-dependent, albeit their levels seem to be dependent on endometrial category in the mid-luteal phase. This study suggests that enzymes existing in NETs may instigate changes on PGF2α mediators, which may become an additional mechanism of fibrogenesis in mare endometrium.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRebordão MR, Amaral A, Fernandes C, Silva E, Lukasik K, Szóstek-Mioduchowska A, Pinto-Bravo P, Galvão A, Skarzynski DJ, Ferreira-Dias G. 2021 Enzymes present in neutrophil extracellular traps may stimulate the fibrogenic PGF(2 alpha) pathway in the mare endometriumm. Animals 11:2615. DOI:10.3390/ani11092615pt_PT
dc.identifier.doi10.3390/ani11092615pt_PT
dc.identifier.issn2076-2615
dc.identifier.urihttp://hdl.handle.net/10400.5/22466
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationPPN/BIL/2018/1/00250/U/0001pt_PT
dc.relationUID/CVT/276/2013pt_PT
dc.relationNot Available
dc.relation.publisherversionhttps://www.mdpi.com/2076-2615/11/9/2615pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectNeutrophil extracellular trapspt_PT
dc.subjectFibrosispt_PT
dc.subjectEndometriumpt_PT
dc.subjectEndometrosispt_PT
dc.subjectHorsept_PT
dc.subjectPGF2αpt_PT
dc.subjectPGF2α receptorpt_PT
dc.titleEnzymes present in neutrophil extracellular traps may stimulate the fibrogenic PGF(2 alpha) pathway in the mare endometriumpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/157379/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/142833/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/DL 57%2F2016/DL 57%2F2016%2FCP1438%2FCT0001/PT
oaire.citation.conferencePlaceSWITZERLANDpt_PT
oaire.citation.issue2615pt_PT
oaire.citation.titleAnimalspt_PT
oaire.citation.volume11(9)pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
oaire.fundingStreamDL 57/2016
person.familyNameRebordão Cordeiro Simões Crisóstomo
person.familyNameAmaral
person.familyNameTomé Sousa Silva
person.familyNameSzóstek-Mioduchowska
person.familyNameBravo
person.familyNameLeitão Ferreira-Dias
person.givenNameMaria Rosa
person.givenNameAna
person.givenNameMaria Elisabete
person.givenNameAnna
person.givenNamePedro
person.givenNameGraça Maria
person.identifier.ciencia-id9515-257A-B35D
person.identifier.ciencia-idEB18-9420-421B
person.identifier.ciencia-id651A-9A4A-1CE0
person.identifier.ciencia-id8516-DDA2-7955
person.identifier.ciencia-id831C-3948-CF5C
person.identifier.ciencia-idF51C-7F45-C720
person.identifier.orcid0000-0002-4389-445X
person.identifier.orcid0000-0002-0075-262X
person.identifier.orcid0000-0002-2332-7642
person.identifier.orcid0000-0003-4204-1698
person.identifier.orcid0000-0001-9442-7539
person.identifier.orcid0000-0003-0622-6513
person.identifier.scopus-author-id56394000500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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