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Interferon-gamma at the crossroads of tumor immune surveillance or evasion

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dc.contributor.authorCastro, Flávia
dc.contributor.authorCardoso, Ana Patrícia
dc.contributor.authorGonçalves, Raquel Madeira
dc.contributor.authorSerre, Karine
dc.contributor.authorOliveira, Maria José
dc.date.accessioned2021-03-25T12:37:51Z
dc.date.available2021-03-25T12:37:51Z
dc.date.issued2018
dc.descriptionCopyright © 2018 Castro, Cardoso, Gonçalves, Serre and Oliveira. This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these termspt_PT
dc.description.abstractInterferon-gamma (IFN-γ) is a pleiotropic molecule with associated antiproliferative, pro-apoptotic and antitumor mechanisms. This effector cytokine, often considered as a major effector of immunity, has been used in the treatment of several diseases, despite its adverse effects. Although broad evidence implicating IFN-γ in tumor immune surveillance, IFN-γ-based therapies undergoing clinical trials have been of limited success. In fact, recent reports suggested that it may also play a protumorigenic role, namely, through IFN-γ signaling insensitivity, downregulation of major histocompatibility complexes, and upregulation of indoleamine 2,3-dioxygenase and of checkpoint inhibitors, as programmed cell-death ligand 1. However, the IFN-γ-mediated responses are still positively associated with patient's survival in several cancers. Consequently, major research efforts are required to understand the immune contexture in which IFN-γ induces its intricate and highly regulated effects in the tumor microenvironment. This review discusses the current knowledge on the pro- and antitumorigenic effects of IFN-γ as part of the complex immune response to cancer, highlighting the relevance to identify IFN-γ responsive patients for the improvement of therapies that exploit associated signaling pathways.pt_PT
dc.description.sponsorshipThis article is a result of the project NORTE-01-0145-FEDER-000012, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) and through the FCT PhD Programmes by Human Capital Operational Programme (POCH), specifically by the BiotechHealth Programme. FC and RG, KS, and MO also acknowledge FCT for PhD grant (PD/BD/114013/2015) and for the FCT Investigator Grants (IF/00638/2014, IF/00004/2014 and IF/01066/2012), respectively. AC has a postdoctoral fellowship (POCI-01-0145-FEDER-016390). KS received an iMM Laço-2016 research grant.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFront Immunol. 2018 May 4;9:847pt_PT
dc.identifier.doi10.3389/fimmu.2018.00847pt_PT
dc.identifier.eissn1664-3224
dc.identifier.urihttp://hdl.handle.net/10451/47057
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relationNORTE-01-0145-FEDER-000012pt_PT
dc.relationDevelopment of an immunomodulatory delivery system to prevent cancer cell invasion and metastasis
dc.relationIF/01066/2012pt_PT
dc.relationIF/00004/2014pt_PT
dc.relationPOCI-01-0145-FEDER-016390pt_PT
dc.relation.publisherversionhttps://www.frontiersin.org/journals/immunologypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCancer microenvironmentpt_PT
dc.subjectImmune contexturept_PT
dc.subjectImmunoregulationpt_PT
dc.subjectImmunotherapypt_PT
dc.subjectType II interferonpt_PT
dc.titleInterferon-gamma at the crossroads of tumor immune surveillance or evasionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberPD/BD/114013/2015
oaire.awardTitleDevelopment of an immunomodulatory delivery system to prevent cancer cell invasion and metastasis
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/PD%2FBD%2F114013%2F2015/PT
oaire.citation.titleFrontiers in Immunologypt_PT
oaire.citation.volume9pt_PT
oaire.fundingStreamOE
person.familyNameSerre
person.givenNameKarine
person.identifier120366
person.identifier.ciencia-id1E11-7283-DF35
person.identifier.orcid0000-0001-9152-4739
person.identifier.scopus-author-id6602493849
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationca6a906a-8017-40b3-9692-8c72c063c339
relation.isAuthorOfPublication.latestForDiscoveryca6a906a-8017-40b3-9692-8c72c063c339
relation.isProjectOfPublication2b6940cf-47f9-44ba-90ac-53a1f77af00a
relation.isProjectOfPublication.latestForDiscovery2b6940cf-47f9-44ba-90ac-53a1f77af00a

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