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High-caloric diet Induces memory impairment and disrupts synaptic plasticity in aged rats

2021Artigo científico Acesso aberto
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dc.contributor.authorPaulo, Sara L
dc.contributor.authorMiranda-Lourenço, Catarina
dc.contributor.authorBelo, Rita F.
dc.contributor.authorRodrigues, Rui S.
dc.contributor.authorFonseca-Gomes, João
dc.contributor.authorTanqueiro, Sara
dc.contributor.authorGeraldes, Vera
dc.contributor.authorRocha, Isabel
dc.contributor.authorSebastião, Ana M
dc.contributor.authorXapelli, Sara
dc.contributor.authorDiógenes, Maria José
dc.date.accessioned2022-01-04T13:43:02Z
dc.date.available2022-01-04T13:43:02Z
dc.date.issued2021
dc.description© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractThe increasing consumption of sugar and fat seen over the last decades and the consequent overweight and obesity, were recently linked with a deleterious effect on cognition and synaptic function. A major question, which remains to be clarified, is whether obesity in the elderly is an additional risk factor for cognitive impairment. We aimed at unravelling the impact of a chronic high caloric diet (HCD) on memory performance and synaptic plasticity in aged rats. Male rats were kept on an HCD or a standard diet (control) from 1 to 24 months of age. The results showed that under an HCD, aged rats were obese and displayed significant long-term recognition memory impairment when compared to age-matched controls. Ex vivo synaptic plasticity recorded from hippocampal slices from HCD-fed aged rats revealed a reduction in the magnitude of long-term potentiation, accompanied by a decrease in the levels of the brain-derived neurotrophic factor receptors TrkB full-length (TrkB-FL). No alterations in neurogenesis were observed, as quantified by the density of immature doublecortin-positive neurons in the hippocampal dentate gyrus. This study highlights that obesity induced by a chronic HCD exacerbates age-associated cognitive decline, likely due to impaired synaptic plasticity, which might be associated with deficits in TrkB-FL signaling.pt_PT
dc.description.sponsorshipThis research was funded by Santa Casa da Misericórdia de Lisboa—MB37-2017; Fundação para a Ciência e a Tecnologia (FCT)—IF/01227/2015; and it received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 952455. Researchers were supported by the following: S.L.P.—FCT (PD/BD/150341/2019); C.M.-L.—FCT (SFRH/BD/118238/2016) and Universidade de Lisboa (BD2015); R.F.B.—FCT (PD/BD/114337/2016); R.S.R.—FCT (SFRH/BD/129710/2017); S.R.T.—FCT (SFRH/BD/128091/2016).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCurr Issues Mol Biol. 2021 Dec 18;43(3):2305-2319pt_PT
dc.identifier.doi10.3390/cimb43030162pt_PT
dc.identifier.eissn1467-3045
dc.identifier.issn1467-3037
dc.identifier.urihttp://hdl.handle.net/10451/50686
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationEpileptogenesis and Epilepsy Network: from genes, synapses and circuits to pave the way for novel drugs and strategies
dc.relationA definir
dc.relationRegulation of adenosine levels as a new therapeutic strategy for Rett Syndrome
dc.relationKyotorphin as new pharmacological therapeutic strategy for Alzheimers Disease
dc.relationCB2ExStress: a neurogenic strategy to tackle mood disorders
dc.relation.publisherversionhttps://www.mdpi.com/journal/cimbpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAgingpt_PT
dc.subjectBrain-derived neurotrophic factor (BDNF)pt_PT
dc.subjectHigh caloric dietpt_PT
dc.subjectHippocampal plasticitypt_PT
dc.subjectMemorypt_PT
dc.subjectNeurogenesispt_PT
dc.subjectObesitypt_PT
dc.titleHigh-caloric diet Induces memory impairment and disrupts synaptic plasticity in aged ratspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEpileptogenesis and Epilepsy Network: from genes, synapses and circuits to pave the way for novel drugs and strategies
oaire.awardTitleA definir
oaire.awardTitleRegulation of adenosine levels as a new therapeutic strategy for Rett Syndrome
oaire.awardTitleKyotorphin as new pharmacological therapeutic strategy for Alzheimers Disease
oaire.awardTitleCB2ExStress: a neurogenic strategy to tackle mood disorders
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/952455/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//PD%2FBD%2F150341%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F118238%2F2016/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//PD%2FBD%2F114337%2F2016/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F129710%2F2017/PT
oaire.citation.endPage2319pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage2305pt_PT
oaire.citation.titleCurrent Issues in Molecular Biologypt_PT
oaire.citation.volume43pt_PT
oaire.fundingStreamH2020
person.familyNamePaulo
person.familyNameMiranda Lourenço
person.familyNameBelo
person.familyNameRodrigues
person.familyNameFonseca-Gomes
person.familyNameTanqueiro
person.familyNameGeraldes
person.familyNamerocha
person.familyNameSebastião
person.familyNameXapelli
person.familyNamede Oliveira Diógenes Nogueira
person.givenNameSara
person.givenNameCatarina
person.givenNameRita
person.givenNameRui S
person.givenNameJoão
person.givenNameSara
person.givenNameVera
person.givenNameisabel
person.givenNameAna M
person.givenNameSara
person.givenNameMaria José
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project.funder.identifierhttp://doi.org/10.13039/501100008530
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
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