Publication
Low CD4 T-cell counts despite low levels of circulating HIV : insights from the comparison of HIV-1 infected patients with a discordant response to antiretroviral therapy to patients with untreated advanced HIV-2 disease
| dc.contributor.author | Albuquerque, A. S. | |
| dc.contributor.author | Foxall, R. B. | |
| dc.contributor.author | Cortesão, C. S. | |
| dc.contributor.author | Soares, R. S. | |
| dc.contributor.author | Doroana, M. | |
| dc.contributor.author | Ribeiro, A. | |
| dc.contributor.author | Lucas, M. | |
| dc.contributor.author | Antunes, F. | |
| dc.contributor.author | Victorino, R. M. | |
| dc.contributor.author | Sousa, A. E. | |
| dc.date.accessioned | 2015-07-14T15:30:38Z | |
| dc.date.available | 2015-07-14T15:30:38Z | |
| dc.date.issued | 2007 | |
| dc.description | © 2007 Elsevier Inc. All rights reserved. | por |
| dc.description.abstract | A significant proportion of HIV-1+ patients with suppression of viremia under antiretroviral therapy fail to recover CD4(+) T-cell counts (ART-Discordants). Similarly, untreated HIV-2+ patients can also exhibit major CD4 depletion in spite of undetectable viremia. We characterize here the immunological disturbances associated with major CD4-lymphopenia in these two scenarios as compared to untreated viremic HIV-1+ patients with similar CD4-lymphopenia and HIV-1+ patients with successful immunological and virological responses under ART. Low CD4 counts were associated with major naive CD4 and CD8 depletion, irrespective of type of infection or ART-exposure. However, ART-Discordants exhibited lower levels of T-cell activation as compared to both untreated HIV-2 and HIV-1 cohorts, and a less marked increase in circulating IL-7 despite similar CD4 depletion. Nevertheless, ART-Discordants showed a preserved Bcl-2 expression, suggesting increased IL-7 consumption, which in conjunction with the relatively lower T-cell activation may contribute to their CD4 count stability and low rate of opportunistic infections. | eng |
| dc.description.sponsorship | This work was supported by grants from “Fundação para a Ciência e Tecnologia” (FCT - POCI/SAU-MMO/60333/2004), “Sociedade Portuguesa de Medicina Interna/GlaxoSmithKline” and “Associação Portuguesa para o Estudo Clínico da SIDA/Bristol-Myers Squibb” to AES. ASA, RBF, CSC and RSS received scholarships from FCT. | eng |
| dc.identifier.citation | Clinical Immunology (2007) 125, 67–75 | por |
| dc.identifier.issn | 1521-6616 | |
| dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S1521661607012764 | |
| dc.identifier.uri | http://dx.doi.org/10.1016/j.clim.2007.07.001 | |
| dc.identifier.uri | http://hdl.handle.net/10451/18446 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Elsevier | por |
| dc.relation.publisherversion | The definitive version is available at http://www.sciencedirect.com | eng |
| dc.subject | HIV/AIDS | eng |
| dc.subject | HIV-2 | eng |
| dc.subject | Antiretroviral therapy | eng |
| dc.subject | Immunological reconstitution | eng |
| dc.subject | IL-7 | eng |
| dc.subject | T-cell activation | eng |
| dc.title | Low CD4 T-cell counts despite low levels of circulating HIV : insights from the comparison of HIV-1 infected patients with a discordant response to antiretroviral therapy to patients with untreated advanced HIV-2 disease | eng |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/POCI/POCI%2FSAU-MMO%2F60333%2F2004/PT | |
| oaire.citation.title | Clinical Immunology | eng |
| oaire.fundingStream | POCI | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | closedAccess | por |
| rcaap.type | article | por |
| relation.isProjectOfPublication | 85b488bd-72f8-4ef4-99b0-aeefce9e6b59 | |
| relation.isProjectOfPublication.latestForDiscovery | 85b488bd-72f8-4ef4-99b0-aeefce9e6b59 |