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Low-dose Colchicine in coronary artery disease : systematic review and meta-analysis

2021Artigo científico Acesso aberto
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dc.contributor.authorAbrantes, Ana Mafalda
dc.contributor.authorNogueira Garcia, Beatriz
dc.contributor.authorAlves, Mariana
dc.contributor.authorPassos, Dúlio Teixeira
dc.contributor.authorBrito, Dulce
dc.contributor.authorPinto, Fausto J.
dc.contributor.authorCaldeira, Daniel
dc.date.accessioned2021-09-13T16:56:34Z
dc.date.available2021-09-13T16:56:34Z
dc.date.issued2021
dc.description© 2021, The Japanese Circulation Society. This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license. https://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.description.abstractBackground: Recent studies have revealed the benefits of using colchicine, a drug with anti-inflammatory properties, in coronary artery disease (CAD). This study systematically reviewed the benefits and risks of low-dose colchicine in patients with CAD. Methods and Results: We searched for randomized controlled trials (RCTs) in MEDLINE, the Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science databases (March 2020). Efficacy and safety outcomes were evaluated. Estimates are expressed as risk ratios (RRs) and 95% confidence intervals (95% CIs). Heterogeneity was assessed with I2 test. Confidence in the pooled evidence was appraised using the GRADE framework. Colchicine reduced the rate of major adverse cardiovascular events (RR 0.65; 95% CI 0.49-0.86; 6 RCTs; I2=50%; 11,718 patients; GRADE, moderate confidence), acute coronary syndrome (RR 0.64; 95% CI 0.46-0.90; I2=47%; 7 RCTs; 11,955 patients; GRADE, very low confidence), stroke (RR 0.49; 95% CI 0.30-0.78; I2=0%; 6 RCTs; 11,896 patients; GRADE, moderate confidence), and cardiovascular interventions (RR 0.61; 95% CI 0.42-0.89; I2=40%; 4 RCTs; 11,284 patients; GRADE, high confidence). Colchicine did not increase the risk of adverse events, except for gastrointestinal events (RR 1.54; 95% CI 1.11-2.13; I2=72%; 9 RCTs; 12,374 patients; GRADE, very low confidence). Conclusions: Low-dose colchicine in patients with CAD is associated with beneficial effects on prognosis, although an increased risk of gastrointestinal events was confirmed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCirc Rep. 2021 Jul 15;3(8):457-464pt_PT
dc.identifier.doi10.1253/circrep.CR-21-0065pt_PT
dc.identifier.eissn2434-0790
dc.identifier.urihttp://hdl.handle.net/10451/49509
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherThe Japanese Circulation Societypt_PT
dc.relation.publisherversionhttps://www.jstage.jst.go.jp/browse/circrep/-char/enpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAtherosclerosispt_PT
dc.subjectColchicinept_PT
dc.subjectCoronary artery diseasept_PT
dc.subjectInflammationpt_PT
dc.titleLow-dose Colchicine in coronary artery disease : systematic review and meta-analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage464pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage457pt_PT
oaire.citation.titleCirculation Reportspt_PT
oaire.citation.volume3pt_PT
person.familyNameAbrantes
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person.familyNameT. Passos
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person.givenNameAna Mafalda
person.givenNameMariana
person.givenNameDúlio
person.givenNameDulce
person.givenNameFausto J.
person.givenNameDaniel
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rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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