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On the contribution of Angola to the initial spread of HIV-1

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dc.contributor.authorPineda-Peña, Andrea-Clemencia
dc.contributor.authorVaranda, Jorge
dc.contributor.authorSousa, João Dinis
dc.contributor.authorTheys, Kristof
dc.contributor.authorBártolo, Inês
dc.contributor.authorLeitner, Thomas
dc.contributor.authorTaveira, Nuno
dc.contributor.authorVandamme, Anne-Mieke
dc.contributor.authorAbecasis, Ana B.
dc.date.accessioned2023-08-24T10:48:26Z
dc.date.available2023-08-24T10:48:26Z
dc.date.issued2016
dc.date.updated2023-02-03T14:26:45Z
dc.description.abstractAngola borders and has long-term links with Democratic Republic of Congo (DRC) as well as high levels of Human Immunodeficiency Virus (HIV) genetic diversity, indicating a potential role in the initial spread of the HIV-1 pandemic. Herein, we analyze 564 C2V3 and 354 pol publicly available sequences from DRC, Republic of Congo (RC) and Angola to better understand the initial spread of the virus in this region. Phylogeographic analyses were performed with the BEAST software. While our results pinpoint the origin of the pandemic to Kinshasa (DRC) around 1906, the introduction of HIV-1 to Angola could have occurred early between the 1910s and 1940s. Furthermore, most of the HIV-1 migrations out of Kinshasa were directed not only to Lubumbashi and Mbuji-Mayi (DRC), but also to Luanda and Brazzaville. Kinshasa census records corroborate these findings, indicating that the early exportation of the virus to Angola might be related to the high number of Angolans in Kinshasa at that time, originated mostly from the North of Angola. In summary, our results place Angola at the epicenter of the early HIV dissemination, together with DRC and RC.pt_PT
dc.description.sponsorshipThis study was supported by European Funds through grant ‘BioMolecular and Epidemiological Surveillance of HIV Transmitted Drug Resistance, Hepatitis Co-Infections and Ongoing Transmission Patterns in Europe - BEST HOPE - (project funded through HIVERA: Harmonizing Integrating Vitalizing European Research on HIV/Aids, grant 249697)’; by L'Oréal Portugal Medals of Honor for Women in Science 2012 (financed through L'Oréal Portugal, Comissão Nacional da Unesco and Fundação para a Ciência e Tecnologia (FCT - http://www.fct.pt)); by FCT for funds to GHTM-UID/Multi/04413/2013; by the Fonds voor Wetenschappelijk Onderzoek – Flanders (FWO) grant G.0692.14 and G.0611.09N; by a National Institutes of Health (NIH) grant AI087520; by FCT (grants PTDC/SAU-EPI/122400/2010, VIH/SAU/0029/2011 and PTDC/AFR/100646/2008); and by CRIA/ANT/04038/2013; and by National Endowment for the Humanities Collaborative Research Grant No. RZ5152313, "An International Collaboration on the Political, Social, and Cultural History of the Emergence of HIV/AIDS." The computational resources and services used in this work were provided by the Hercules Foundation and the Flemish Government – department EWI-FWO Krediet aan Navorsers (Theys, KAN2012 1.5.249.12.). I.B. is supported by a post-doc fellowship (SFRH/BPD/76225/2011) from FCT. K.T. is supported by a postdoctoral grant from FWO.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPineda-Peña AC, Varanda J, Sousa JD, Theys K, Bártolo I, Leitner T, et al. On the contribution of Angola to the initial spread of HIV-1. Infection, Genetics and Evolution [Internet]. 1 de dezembro de 2016;46:219–22. Disponível em: https://www.sciencedirect.com/science/article/pii/S156713481630346Xpt_PT
dc.identifier.doi10.1016/j.meegid.2016.08.009pt_PT
dc.identifier.eid2-s2.0-84996590196
dc.identifier.slugcv-prod-1108454
dc.identifier.urihttp://hdl.handle.net/10451/58986
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationHarmonizing, Integrating and Vitalizing European Research on hiv/Aids
dc.relationGlobal Health and Tropical Medicine
dc.relationMolecular epidemiology, drug resistance and pathogenesis of HIV and TB in Angola: the Angolan PErinatal HIV Cohort (APEHC)
dc.relationCentre for Research in Anthropology
dc.relationDESENVOLVIMENTO DE NOVOS MICROBICIDAS PARA PREVENIR A INFECÇÃO POR VIH
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S156713481630346Xpt_PT
dc.subjectAngolapt_PT
dc.subjectHIV-1pt_PT
dc.subjectOriginpt_PT
dc.subjectGroup Mpt_PT
dc.subjectPhylogeographypt_PT
dc.titleOn the contribution of Angola to the initial spread of HIV-1pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHarmonizing, Integrating and Vitalizing European Research on hiv/Aids
oaire.awardTitleGlobal Health and Tropical Medicine
oaire.awardTitleMolecular epidemiology, drug resistance and pathogenesis of HIV and TB in Angola: the Angolan PErinatal HIV Cohort (APEHC)
oaire.awardTitleCentre for Research in Anthropology
oaire.awardTitleDESENVOLVIMENTO DE NOVOS MICROBICIDAS PARA PREVENIR A INFECÇÃO POR VIH
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/HIVERA%2F0001%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/249697/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04413%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-EPI%2F122400%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/VIH%2FSAU%2F0029%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FAFR%2F100646%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FANT%2F04038%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F76225%2F2011/PT
oaire.citation.endPage222pt_PT
oaire.citation.startPage219pt_PT
oaire.citation.titleInfection, Genetics and Evolutionpt_PT
oaire.citation.volume46pt_PT
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rcaap.cv.cienciaid661E-F5CB-F85A | Inês Bártolo
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